Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,831 – 4,845 of 60,549 results

4,831

Medchemexpress LLC Methylprednisolone succinate (sodium) | 2375-03-3 | 98.0% | 25 MG

Methylprednisolone succinate (sodium) | 2375-03-3 | 98.0% | 25 MG

Pricing & Availability

4,832

Medchemexpress LLC TS-002266 | 2702325-64-0 | 99.0% | 639.53 g/mol | 25 MG

TS-002266 is a small molecule TUT4/7 inhibitor with anti-leukemic effects. TS-002266 is promising for research of cancers.

TUT4/7 inhibitor
Anti-leukemic effects
Promising for research of cancers

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4,833

Cayman Chemical NVP-BKM120, Purity: ≥95%, CAS: 944396-07-0, 5 mg

An inhibitor of the class I PI3K isoforms p110α (IC50 = 52 nM) and p110β (IC50 = 166 nM); selective for these isoforms over the class III PI3K Vps34 (IC50 = 2,410 nM), mTOR (IC50 = 2,866 nM), PI4Kβ (IC50 = >25,000 nM), and a variety of kinases (IC50s = >10,000 nM); inhibits proliferation of human tumor and glioma cell lines, with p53 wild-type glioma cells more sensitive than p53 mutant/deleted glioma cells (IC50s = 1.28 and 2.08 µM, respectively); crosses the blood brain barrier; increases survival in a U87 glioma mouse xenograft intracranial tumor model when orally administered at 20 and 40 mg/kg once per week

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4,834

ABclonal Technology Thymidylate synthase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 10-methylenetetrahydrofolate (methylene-THF) as a cofactor This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair The enzyme has been of interest as a target for cancer chemotherapeutic agents It is considered to be the primary site of action for 5-fluorouracil 5-fluoro-2-prime-deoxyuridine and some folate analogs Expression of this gene and that of a naturally occurring antisense transcript mitochondrial enolase superfamily member 1 (GeneID 55556) vary inversely when cell-growth progresses from late-log to plateau phase Polymorphisms in this gene may be associated with etiology of neoplasia including breast cancer and response to chemotherapy

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4,835

Cayman Chemical Florfenicol amine (hydrochloride), Purity: ≥95%, CAS: 108656-33-3, 5 mg

A metabolite of florfenicol

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4,836

Medchemexpress LLC Cyclopropanecarbonitrile, 2-(7-chloro-2-(5-chloro-3-(trifluoromethyl)-pyrazol-1-yl)methyl-) | 2026635-66-3 | 99.1% | 428.20 g/mol | C17H10Cl2F3N5O | 5 MG

GNE 5729 is a brain-permeable positive allosteric modulator of the NMDA receptor (NMDAR) with preferential potency at GluN2A subunits. It is used in biochemical, cellular, and in vivo pharmacology studies to probe NMDAR modulation and subtype selectivity.

Brain-permeable compound suitable for central nervous system studies.
High potency at GluN2A with EC50 = 37 nM.
Lower potency at GluN2C and GluN2D (EC50 = 4.7 μM and 9.5 μM) indicating subtype selectivity.
High purity (99.1% by LCMS) suitable for pharmacology assays.
Solid form, white to yellow, stable for handling and storage.

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4,837

Medchemexpress LLC WIF-1 Human HEK293 1mg

Recombinant human WIF-1 protein expressed in HEK293 cells and supplied as a lyophilized, C-terminal His-tagged preparation. WIF-1 binds WNT proteins and inhibits WNT signaling; this product is provided with high purity and recommended handling and storage instructions for research use. The material has an approximate molecular weight of 42-48 kDa and is intended for studies of WNT pathway regulation and protein interactions.

High purity (≥95%) for reproducible experimental results.
HEK293 expression preserves human-like post-translational modifications.
C-terminal His tag enables straightforward purification and detection.
Lyophilized format for extended shelf life and convenient storage.
Recommended reconstitution at ≥100 μg/mL to maintain stability.
Stable when stored at -20°C; aliquot and freeze at -20°C or -80°C for long-term storage.
Suitable for functional and binding studies of WNT signaling.

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4,838

Cayman Chemical TAE684, Purity: ≥95%, CAS: 761439-42-3, 10 mg

A selective ALK inhibitor that blocks the proliferation of ALCL-derived and ALK-dependent cell lines (IC50s = 2-5 nM); suppresses tumor growth in in vivo models of ALK-positive ALCL and neuroblastoma; also inhibits the activity of the Parkinson’s disease-linked LRRK2 (IC50s = 7.8 and 6.1 nM for wild-type and G2019S mutant LRRK2, respectively)

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4,839

Cayman Chemical DMOG, Purity: ≥98%, CAS: 89464-63-1, 10 mg

A cell permeable, competitive inhibitor of HIF-1α prolyl hydroxylase; stabilizes HIF-1α expression at normal oxygen tensions in cultured cells at concentrations between 0.1 and 1 mM

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4,840

Medchemexpress LLC HY-101792A 10mg , RG7800 hydrochloride CAS: Purity:>98%

HY-101792A 10mg RG7800 hydrochloride CAS: RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,841

Cayman Chemical Drimentine A, Purity: ≥85%, CAS: 204398-90-3, 5 mg

A terpenylated diketopiperazine

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4,842

Selleck Chemical LLC Ripretinib S8757-25MG

Ripretinib is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) Kit (c-Kit) and PDGFR-alpha with IC50 values of 4 nM 8 nM 18 nM 5 nM and 14 nM for WT Kit (c-Kit) V654A Kit (c-Kit) T670I Kit (c-Kit) D816H Kit (c-Kit) and D816V Kit (c-Kit) respectively

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4,843

Medchemexpress LLC Fosravuconazole (L-lysine ethanolate) | 914361-45-8 | 99.9% | 739.73 | 25 MG

Fosravuconazole L-lysine ethanolate, a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. It can be used for candidiasis, onychomycosis, and parasitemia research.

Proagent of Ravuconazole
Orally active broad spectrum antifungal agent
Used for candidiasis research
Used for onychomycosis research
Used for parasitemia research
Potent in vitro antifungal activity against a wide range of fungal species, including Candida, Aspergillus, and Trichophyton species
Suppresses parasitemia and prevents death in mice infected with the T. cruzi Y strain (In Vivo data)

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4,844

Medchemexpress LLC Adipic acid-d10 | 25373-21-1 | MFCD00190459 | 99.9% | 156.20 g/mol | C6D10O4 | 25 MG

Adipic acid-d10 is the deuterium-labeled isotopologue of adipic acid supplied for research use as a stable-isotope tracer and internal standard for quantitative analysis. It provides high chemical purity and deuterium enrichment suitable for NMR, GC-MS, and LC-MS method development and isotopic labeling studies.

Used as a stable-isotope tracer for quantitative studies.
Serves as an internal standard for NMR, GC-MS, and LC-MS.
High chemical purity and deuterium enrichment for reliable results.
Suitable for analytical method development and validation.
Supplied for research use only; not for human consumption.

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4,845

Medchemexpress LLC HY-108741 5mg , Plecanatide CAS:467426-54-6 Purity:>98%

HY-108741 5mg Plecanatide CAS: 467426-54-6 Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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Medchemexpress LLC Methylprednisolone succinate (sodium) | 2375-03-3 | 98.0% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC TS-002266 | 2702325-64-0 | 99.0% | 639.53 g/mol | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

ABclonal Technology Thymidylate synthase Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cyclopropanecarbonitrile, 2-(7-chloro-2-(5-chloro-3-(trifluoromethyl)-pyrazol-1-yl)methyl-) | 2026635-66-3 | 99.1% | 428.20 g/mol | C17H10Cl2F3N5O | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC WIF-1 Human HEK293 1mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-101792A 10mg , RG7800 hydrochloride CAS: Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Fosravuconazole (L-lysine ethanolate) | 914361-45-8 | 99.9% | 739.73 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Adipic acid-d10 | 25373-21-1 | MFCD00190459 | 99.9% | 156.20 g/mol | C6D10O4 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-108741 5mg , Plecanatide CAS:467426-54-6 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More